Reed Lab

R. Das, Z. Zhou, and R. Reed (2000) Functional association of U2 snRNP with the ATP-independent spliceosomal complex E. Molecular Cell 5: 779-787.

Z. Zhou*, M.-J. Luo*, K. Straesser, J. Katahira, E. Hurt, and R. Reed (2000) The protein Aly links pre-messenger-RNA splicing to nuclear export. Nature 407: 401-405. *these authors contributed equally to this work

K. N. Clouse*, M.-J. Luo*, Z. Zhou, and R. Reed (2001) A Ran independent pathway for mRNA export. Nature Cell Biol. 3: 97-99. *these authors contributed equally to this work

K. Chua and R. Reed (2001) An upstream AG determines whether a downstream AG is selected during catalytic step II of splicing. Mol. Cell. Biol. 5: 1509-14.

M.-J. Luo, Z. Zhou, K. Magni, C. Christoforides, J. Rappsilber, M. Mann, and R. Reed (2001) Coupling pre-mRNA splicing and mRNA export through direct interactions between UAP56 and Aly. Nature 413: 644-647.

K. Strasser, S. Masuda, P. Mason, J. Pfannstiel, M. Oppizzi, S. Rodriguez-Navarro, A. G. Rondon, A. Aguilera, K. Struhl, R. Reed, and E. Hurt (2002) TREX is a conserved complex coupling transcription with messenger RNA export. Nature 417: 304-308.

Z. Zhou, J. Sim, J. Griffith and R. Reed (2002) Purification and visualization of functional human spliceosomes. PNAS 99: 12203-12207.

Z. Zhou, L. Licklider, S. Gygi, and R. Reed (2002) Comprehensive analysis of the human spliceosome. Nature 419: 182-185.

S Chung, Z Zhou, KA Huddleston, DA Harrison, R Reed, TA Coleman, BC Rymond. (2002) Crooked neck is a component of the human spliceosome and implicated in the splicing process. Biochim Biophys Acta 1576:287-97.

Rodríguez-Navarro S, Fischer T, Luo MJ, Antúnez O, Brettschneider S, Lechner J, Pérez-Ortín JE,Reed R, Hurt E. (2004) Sus1, a functional component of the SAGA histone acetylase complex and the nuclear pore-associated mRNA export machinery. Cell 116:75-86.

Hurt E, Luo MJ, Röther S, Reed R, Strässer K. (2004) Cotranscriptional recruitment of the serine-arginine-rich (SR)-like proteins Gbp2 and Hrb1 to nascent mRNA via the TREX complex. PNAS 101:1858-62.

Ferraiuolo MA, Lee CS, Ler LW, Hsu JL, Costa-Mattioli M, Luo MJ, Reed R, Sonenberg N. (2004) A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense mediated decay. PNAS 101:4118-23.

Seiji Masuda, Rita Das, Hong Cheng, Ed Hurt, Nijsje Dorman and Robin Reed (2005) Recruitment of the human TREX complex to mRNA during splicing. Genes Dev 19: 1512-1517.

El C Ibrahim, TD Schaal, KJ Hertel, R Reed, T Maniatis (2005) Serine/arginine-rich protein-dependent suppression of exon skipping by exonic splicing enhancers. PNAS. :5002-7. Epub 2005 Mar 7.

R. Das, K. Dufu, B. Romney, M. Feldt, M. Elenko, and R. Reed (2006) Functional coupling of RNAP II transcription to spliceosome assembly. Genes Dev 120: 1100-1109.

E C. Ibrahim, M. M. Hims, N. Shomron, C. B. Burge, S. A. Slaugenhaupt and R. Reed (2007) Weak Splicing Signals Flanking Intron Position 6 Mutation Lead to Familial Dysautonomia. Human Mutation 28: 41-53.

M. M. Hims, E. C. Ibrahim, M. Leyne, J. Mull, N. Lui, C. Lazaro, R S.Shetty, S. Gill, J. F. Gusella, R. Reed, and S. A. Slaugenhaupt, (2007). Therapeutic potential and mechanism of kinetin for the treatment of the human splicing disease familial dysautonomia. Journal of Molecular Medicine 85: 149-161.

H. Cheng, K. Dufu, C. Lee, J. Hsu, A. Dias and R. Reed (2006) Human mRNA Export Machinery Recruited to the 5' End of Spliced mRNA. Cell 127: 1389-1400.

Rita Das, Jiong Yu, Zuo Zhang, Melanie Gygi, Adrian Krainer, Steve Gygi and Robin Reed (2007) SR Proteins Function in Coupling RNAP II Transcription to Pre-mRNA Splicing. Molecular Cell 26: 867-881.